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KMID : 1161420190220040384
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Journal of Medicinal Food
2019 Volume.22 No. 4 p.384 ~ p.392
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Thrombin Inhibition: Preliminary Assessment of the Anticoagulant Potential of Turnera subulata (Passifloraceae)
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da Luz Jefferson Romaryo Duarte
do Nascimento Thayse Evellyn Silva
de Morais Leandro Vinicius Fernandes
da Cruz Ana Katarina Menezes
de Rezende Adriana Augusto
Neto Jose Brandao
Ururahy Marcela Abbott Galvao
Luchessi Andre Ducati
Lopez Jorge A.
Rocha Hugo Alexandre Oliveira
das Gracas Almeida Maria
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Abstract
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Cardiovascular and thromboembolic disturbances are the main causes of disease-related deaths worldwide. Regardless of the etiological factors involved in thrombus formation, coagulation is mainly activated by thrombin, one of the most important blood clotting molecules. Thus, this study evaluated the Turnera subulata leaf crude extract, its ethyl acetate fraction effect on the coagulation cascade, and its possible side effects. Their phytocomposition indicated polyphenols, mainly flavonol-3-O-glycosylate and a flavone glycoside, without in vitro and in vivo toxicity. Regarding their potential anticoagulants, results displayed partial thromboplastin and prothrombin time activation, and Xa and IIa, and thrombin inhibition by heparin II cofactor, indicating significant anticoagulant activity, suggesting direct and indirect thrombin inhibition as the main mechanism of action. Therefore, T. subulata leaf active compounds exhibit therapeutic potential required to develop phytotherapeutic formulations to assist conventional anticoagulants in clinical treatments.
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KEYWORD
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clinical therapy, coagulation cascade, plant extract, polyphenols
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